Bcl 1 polymorhpism of glucocorticoid receptor gene in patients with bronchial asthma with obesity

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dc.contributor.authorKmyta, V. V.
dc.contributor.authorGarbuzova, V. Y.
dc.contributor.authorPrystupa, E. N.
dc.contributor.authorPrystupa, L. N.
dc.date.accessioned2018-05-16T16:36:08Z
dc.date.available2018-05-16T16:36:08Z
dc.date.issued2016
dc.descriptionThe objective of this investigation was to analyze possible association between Be!I polymorphism of glucocorticoid receptor gene and obesity in patients with bronchial asthma (BA). The study involved 188patients with bronchial asthma and 95 apparently healthy adult individuals. Generally accepted assessments and examinations for BA diagnosis, and anthropometric, molecular-genetic and statistic methods of investigation were used in the research. It was found out that the patients with BA demonstrated higher body mass index (BMI) and higher ratio of fat centralization much more often, than the control group. Genotypes distribution for Bell polymorphism in patients with BA showed a statistically significant difference between patients with different BMI unlike the control group. Comparison of genotype frequency for Bell polymorphism in glucocorticoid receptor gene in individuals with different ratio of fat centralization in the control group and in the patients with BA separately showed statistically significant differences in the distribution of gene allelic variations only among the patients with BA. It was demonstrated that G/G genotype in the patients with viscera! obesity was associated with BA.uk_UA
dc.identifier.citationBcl 1 polymorhpism of glucocorticoid receptor gene in patients with bronchial asthma with obesity / V. V. Kmyta, V. Y. Garbuzova, E. N. Prystupa, L. N. Prystupa // Цитология и генетика. – 2016. – Т. 50, № 3. – С. 36 – 41. (Scopus)uk_UA
dc.identifier.urihttp://repository.ldufk.edu.ua/handle/34606048/10512
dc.language.isoenuk_UA
dc.subjectбронхіальна астмаuk_UA
dc.subjectbronchial asthmauk_UA
dc.subjectobesityuk_UA
dc.subjectBel 1 polymorphismuk_UA
dc.subjectglucocorticoid receptor geneuk_UA
dc.titleBcl 1 polymorhpism of glucocorticoid receptor gene in patients with bronchial asthma with obesityuk_UA
dc.typeArticleuk_UA

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