Перегляд за Автор "Tymochko-Voloshyn, R."

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Correction of the functional state of 5 - 9 - grade students at rural schools selected for special medical groups due to articular manifestations of connective tissue dysplasia in Ukraine
(2017) Tymochko-Voloshyn, R.; Trach, Volodymyr; Boretsky, Yuriy; Dyka, M.; Тимочко-Волошин, Роксолана; Трач, Володимир; Борецький, Юрій; Дика, М.
The most frequent signs of connective tissue dysplasia and its links with a general morbidity of pupils were summarized. Health problems and some means for physical education of Ukrainian rural school pupils that were classified to special medical group due to connective tissues dysplasia are described in the article. Based on obtained data we tried to develop a complex approach that can be used during school year to stimulate moving activi ty and to improve a functional state of cardio - vascular and respiratory systems of special medical groups pupils possessing joint hypermobility caused by connective tissue dysplasia. Then evaluation of the developed approach was done by studying pupil’s heart rate and applying different tests such as Stange test, Hench test , indexes of Ruffier and Robinson, vegetative index of Kerdo. As a result, positive influence of the developed program on a physical state of pupils enrolled was confirmed. Thus, the de veloped program can be used in Ukrainian rural schools to teach pupils exhibiting connective tissue dysplasia in order to compensate their lack of physical activity and improve their functional state thus preventing morbidity and development of complications.
Regeneration of Skeletal Muscle Fibers and Regulation of Myosatellitocytes Metabolism
(2022-06-24) Hashchyshyn, V.; Tymochko-Voloshyn, R.; Paraniak, N.; Vovkanych, L.; Hlozhyk, I.; Trach, V.; Muzyka, F.; Serafyn, Yu.; Prystupa, E.; Boretsky, Yu.; Гащишин, Віра; Тимочко-Волошин, Роксалана; Параняк, Наталія; Вовканич, Любомир; Гложик, Ірина; Трач, Володимир; Музика, Федір; Серафин, Юрій; Приступа, Євген; Борецький, Юрій
Skeletal muscles are heterogeneous tissue containing different types of muscle fibers. Their distribution depends on heredity, type of exercise, sex, age, and muscle type. In addition, stem cells (myosatellitocytes) are found in large amounts in the muscle tissue. Myosatellitocytes are the main material for regeneration of microtears of muscle fibers always occuring during intensive physical exercises. Myosatellitocytes are capable of long-term storage in an inactive “dormant” state, but they can be rapidly activated to provide an efficient repair of damaged muscle fibers. The metabolism of myosatellitocytes and myoblasts and their migration into the damaged area are regulated by a complex system of cytokines and transcription factors, the activity of which depends on many factors. Microtears initiating the development of the inflammatory process and activation of myosatellitocytes is a determining factor. The study into molecular mechanisms of the relationship between inflammatory processes in muscle tissue and changes in myosatellitocyte metabolism is of fundamental importance and is necessary for the selection of efficient methods for muscle tissue recovery.