Please use this identifier to cite or link to this item: http://repository.ldufk.edu.ua/handle/34606048/10448
Title: The Pleiotropic Nature of rib80, hit1 , and red6 Mutations Affecting Riboflavin Biosynthesis in the Yeast Pichia guilliermondii
Authors: Fayura, Lyubov
Fedorovych, Daria
Prokopiv, Tetiana
Boretsky, Yuriy
Sibirny, Andriy
Keywords: yeast
Regulation of riboflavin biosynthesis
Iron accumulation
Fe–S cluster proteins
Issue Date: 2007
Citation: The Pleiotropic Nature of rib80, hit1 , and red6 Mutations Affecting Riboflavin Biosynthesis in the Yeast Pichia guilliermondii / L. R. Fayura, D. V. Fedorovych, T. M. Prokopiv, Yu. R. Boretsky, A. A. Sibirny // Mikrobiologiya. - 2007. - Vol. 76, N 1. - P. 66 - 71. (Scopus)
Abstract: The yeast Pichia guilliermondii is capable of riboflavin overproduction under iron deficiency. The rib80, hit1 , and red6 mutants of this species, which exhibit impaired riboflavin regulation, are also distinguished by increased iron concentrations in the cells and mitochondria, morphological changes in the mitochondria, as well as decreased growth rates (except for red6 ) and respiratory activity. With sufficient iron supply, the rib80 and red6 mutations cause a 1.5–1.8-fold decrease in the activity of such Fe–S cluster proteins as aconitase and flavocytochrome b2, whereas the hit1 mutation causes a six-fold decrease. Under iron deficiency, the activity of these enzymes was equally low in all of the studied strains.
URI: http://repository.ldufk.edu.ua/handle/34606048/10448
Appears in Collections:Наукові праці професорсько-викладацького складу ЛДУФК в базах даних Scopus, WoS, Tomson Reuters

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