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Назва: Bcl 1 polymorhpism of glucocorticoid receptor gene in patients with bronchial asthma with obesity
Автори: Kmyta, V. V.
Garbuzova, V. Y.
Prystupa, E. N.
Prystupa, L. N.
Ключові слова: бронхіальна астма
bronchial asthma
obesity
Bel 1 polymorphism
glucocorticoid receptor gene
Дата публікації: 2016
Бібліографічний опис: Bcl 1 polymorhpism of glucocorticoid receptor gene in patients with bronchial asthma with obesity / V. V. Kmyta, V. Y. Garbuzova, E. N. Prystupa, L. N. Prystupa // Цитология и генетика. – 2016. – Т. 50, № 3. – С. 36 – 41. (Scopus)
Опис: The objective of this investigation was to analyze possible association between Be!I polymorphism of glucocorticoid receptor gene and obesity in patients with bronchial asthma (BA). The study involved 188patients with bronchial asthma and 95 apparently healthy adult individuals. Generally accepted assessments and examinations for BA diagnosis, and anthropometric, molecular-genetic and statistic methods of investigation were used in the research. It was found out that the patients with BA demonstrated higher body mass index (BMI) and higher ratio of fat centralization much more often, than the control group. Genotypes distribution for Bell polymorphism in patients with BA showed a statistically significant difference between patients with different BMI unlike the control group. Comparison of genotype frequency for Bell polymorphism in glucocorticoid receptor gene in individuals with different ratio of fat centralization in the control group and in the patients with BA separately showed statistically significant differences in the distribution of gene allelic variations only among the patients with BA. It was demonstrated that G/G genotype in the patients with viscera! obesity was associated with BA.
URI (Уніфікований ідентифікатор ресурсу): http://repository.ldufk.edu.ua/handle/34606048/10512
Розташовується у зібраннях:Наукові праці професорсько-викладацького складу ЛДУФК в базах даних Scopus, WoS, Tomson Reuters

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