BCL1 polymorphism of glucocorticoids receptor gene and bronchial asthma

Abstract

We have identified statistically significant differences in genotypes distribution of BclI polymorphism of GR gene in the control group and in patients with BA , homozygous for the minor allele had a higher risk of the disease than the major allele carriers. It was found out that G/G - homozygotes have a fivefold higher risk of BA, than those homozygous for C/C regardless of gender. We demonstrated that BA risk in females, homozygous for the minor allele, is three times higher and in males – 11,3 times higher, as compared with С/С - homozygotes. That is, men with G/G genotype of Bcl1 GR gene polymorphism have the highest risk of BA.